Poets, C. & Bacher, M. (2011). Treatment of upper airway obstruction and
feeding problems in Robin-like phenotype. The Journal of Pediatrics,
Full Text: Poets & Bacher, 2011.pdf
Ruof, H., Hammer, J., Tillmann, B., Ghelfi, D., & Weber, P. (2008).
Neuropsychological, behavioral, and adaptive functioning of Swiss
children with congenital central hypoventilation syndrome. Journal of
Child Neurology, 23(11), 1254-1259.
ABSTRACT: This study collected data about developmental problems in a cohort of children with congenital central hypoventilation syndrome. In 2003, in Switzerland, 11 children with this disease were registered. Nine of them gave their informed consent to participate in the study and were examined. Clinical assessments were conducted, including examinations of neuropsychological, behavioral, and adaptive functions using Kaufman-Assessment Battery for Children, Child Behavior Checklist, and Vineland Adaptive Behavior Scales. The mean age (+/- standard deviation) was 7.5 +/- 2.5 years. The cognitive tests showed problems in working memory functions with a near-to-normal full-range intelligence quotient (87.4 +/- 23.3). The children showed normal values (t-values < 67) on problem scales of behavior, although 5 of the 9 children showed elevated values on the attention and on the social interaction problem scales. Adaptive function problems were identified in communication and daily living skills.
Emancipator, J. L., Storfer-Isser, A., Taylor, H. G., Rosen, C. L., Kirchner,
H. L., Johnson, N. L., Zambito, A. M., & Redline, S. (2006). Variation
of cognition and achievement with sleep-disordered breathing in full-
term and preterm children. Archives of Pediatric and Adolescent Medicine,
OBJECTIVE: Pediatric sleep-disordered breathing (SDB) has a disproportionately high prevalence in children who were preterm infants (preterm children) and is associated with behavioral comorbidity. Exposure to intermittent hypoxemia and sleep disruption may contribute to cognitive impairment. We quantified the association of SDB with cognition and achievement and determined whether preterm children are at a differentially increased risk for SDB-related impairments.
DESIGN: Cross-sectional analyses.
SETTING: Urban community.
PARTICIPANTS: Eight hundred thirty-five children, aged 8 to 11 years. Intervention(s) None.
MAIN OUTCOME MEASURES: Scores on the Peabody Picture Vocabulary Test-Revised, Kaufman Assessment Battery for Children, and Continuous Performance Test.
RESULTS: One hundred sixty-four children had SDB. In unadjusted analyses, children with SDB had poorer scores on almost all tests of cognition and achievement. Group differences were attenuated after adjusting for socioeconomic status; in these analyses, children with SDB scored lower on the Peabody Picture Vocabulary Test-Revised (mean +/- SE score, 100.5 +/- 1.4 vs 103.6 +/- 0.7; P = .04), and the Kaufman Assessment Battery for Children riddles and triangles subscales. Associations were stronger in preterm than in full-term children. Of the sleep measures, snoring history was most strongly correlated with indices of cognition and achievement.
CONCLUSIONS: Although moderate group differences were observed for almost all cognitive measures, an attenuation of effects was observed once socioeconomic status was considered. The deficits in selective measures of academic abilities, language comprehension, and planning and organizational skills suggest a negative impact of SDB on achievement and cognition. Stronger associations in preterm children suggest the importance of screening for snoring, a good predictor of cognitive function in this population.