Kidney Disease
Falger, J., Latal, B., Landolt, M., Lehmann, P., Neuhaus, T. J., & Laube, G. F.
(2008). Outcome after renal transplantation, Part I: Intellectual and motor
performance. Pediatric Nephrology, 23(8), 1339-1345.
ABSTRACT: Comprehensive information on neurodevelopmental outcome in children and adolescents with chronic kidney disease is still limited. Intellectual performance (IP) and motor performance (MP) were systematically assessed in 27 patients at a median age of 14.1 years (range 6.5–17) and 6 years (range 0.5–12.7) after renal transplantation (RTPL). IP was analyzed with the Wechsler Intelligence Scale for Children-III (WISC-III) in 25 patients and by the Kaufman Assessment Battery for Children in two patients. MP was evaluated by the Zurich Neuromotor Assessment. Median full- scale intelligent quotient (FSIQ) was 97 (range 49–133). Twenty-one patients had an FSIQ ≥ 85 (i.e. ≥ mean–1 standard deviation). The five patients with neurological comorbidity had a median FSIQ of 81 (range 49–101). Verbal IQ (VIQ) (median 104; range 50–146) was significantly ( p < 0.01) higher than performance IQ (PIQ) (median 88; range 48–117). The PIQ was significantly lower compared with controls ( p < 0.007), and patients scored significantly lower compared with controls in five of 11 subtests of the Wechsler Scale. All MP tasks were significantly ( p < 0.01) lower than in controls, and also in children without neurological comorbidity. Socioeconomic status was significantly correlated with FSIQ ( p = 0.03). IP after RTPL was within the normal range for the majority of children. PIQ was lower compared with VIQ, and MP was significantly affected in all children after RTPL.
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